Nathaniel J. Rhodes
Chicago College of Pharmacy, and the Pharmacometrics Center of Excellence, Midwestern University
Statistical power analysis simulation results are provided for determining the “worst-case” sample size assuming minimal measurement precision and relatively weak or moderate effect strengths. In simulated trials with relatively weak effects (ESS = 24%), greater than 80% and greater than 90% power is achieved for equal sample sizes for unit-weighted analyses of one comparison at n = 70 and n= 90 subjects per group. For simulated trials with moderate effects (ESS=48%) greater than 80 and greater than 90% power was achieved for the same conditions at n = 20 and n = 25 subjects per group. A simulation-based approach is useful for determining the “worst-case” sample sizes in various applications.