UniODA vs. t-Test: Low Brain Uptake of L-[11C]5-hydroxytryptophan in Major Depression

Paul R. Yarnold

Optimal Data Analysis, LLC

Prior research employed t-test to compare mean uptake of [11C]5-HTP across the blood-brain barrier for eight healthy volunteers versus six patients with unipolar depression, however no statistically significant mean difference was identified for basil ganglia, caudate nucleus, or lentiform nucleus. When analyzed via UniODA, significantly lower mean uptake was identified for basil ganglia and caudate nucleus.

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